Fluticasone propionate (also known as Fluticasone 17-Propionate ,Flixotide) is a synthetic corticosteroid that potently activates the glucocorticoid receptor (Kd = 0.5 nM). As second generation glucocorticoid, it can enhance eosinophil apoptosis in a concentration-dependent manner via the glucocorticoid receptor and therefore is used as an anti-inflammatory agent for asthma, allergic rhinitis and other airway diseases.
A dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology.
A pilot study of fluticasone propionate in untreated coeliac disease.
Synthesis and structure-activity relationships in a series of antiinflammatory corticosteroid analogues, halomethyl androstane-17 beta-carbothioates and -17 beta-carboselenoates.
In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids.
Local and systemic safety of intranasal corticosteroids.
A review of the clinical efficacy and safety of MP-AzeFlu, a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate, in clinical studies conducted during different allergy seasons in the US.
Eosinophilic Esophagitis: An Evidence-Based Approach to Therapy.