Ethyl 2,2-difluorohexanoate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-difluoro hexanoic acid ethyl ester, 2,2-difluorhexansaeureethylester
Difluoromethyl Building Blocks
KUMI2F60
74106-81-3
MFCD11007687
10464909
2080496
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Ethyl 2,2-difluorohexanoate
C8H14F2O2
180.20
≥96.0%(GC)
Brown Liquid
200-203°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
Ethyl 2,2-difluorohexanoate is a useful starting material and building block for the synthesis of lubiprostone, a drug used in the management of chronic idiopathic constipation,predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.
The asymmetric synthesis of CF3- or –CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst. [1]
Studies toward the oxidative and reductive activation of C-S bonds in 2'-S-aryl-2'-thiouridine derivatives. [2]
References:
[1] J.Lin, et al, Chem. Commun., 2012, 48(62), pp 7738-7740.
[2] R.Rayala, et al, Tetrahedron, 2016, 72(16), pp 1969-1977.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H302+H312+H332,H315,H319,H335
P280,P210
2915.90.7000
UN1993 3/PG III

1. Product Specification
2. Safety Data Sheet
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