Ethyl 2,2-difluorohexanoateis a useful starting material and building block for the synthesis of lubiprostone, a drug used in the management of chronic idiopathic constipation,predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.
The asymmetric synthesis of CF3- or –CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst. 
Studies toward the oxidative and reductive activation of C-S bonds in 2'-S-aryl-2'-thiouridine derivatives. 
 J.Lin, et al, Chem. Commun., 2012, 48(62), pp 7738-7740.
 R.Rayala, et al, Tetrahedron, 2016, 72(16), pp 1969-1977.