2-Chloro-2,2-difluoro-1-phenylethanone

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
2-chloro-2,2-difluoroacetophenone, Chlorodifluoromethyl phenyl ketone
Difluoromethylating Reagent, Difluorocarbene Precursor
KUMI2F20
384-67-8
MFCD00042123
329768330
2251448
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2-Chloro-2,2-difluoro-1-phenylethanone
C8H5ClF2O
190.58
≥97%(GC)
Yellow Clear Liquid
94-96ºC/35 mmHg(lit.)
1ml,5ml,10ml,50ml,100ml and 500ml
Store at room temperature
This reagent is an effective difluorocarbene precursor for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.
2-Chloro-2,2-difluoroacetophenone:  A Non-ODS-Based Difluorocarbene Precursor and Its Use in the Difluoromethylation of Phenol Derivatives. [1]
Reference:
[1] L.Zhang, J.Zhang, J.Hu, J.Org.Chem., 2006, 71(26), pp 9845-9848.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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