2-(trimethylsilyl)-2,2-difluoride ethyl acetate(TMSCF2CO2Et) is used for a C–H difluoromethylation of arenes in an electrophilic radical substitution process. It can be also employed in an efficient and on-pot synthesis of (ethoxycarbonyl)difluoromethyl thioethers.
Ethyl Difluoro(trimethylsilyl)acetate and Difluoro(trimethylsilyl)acetamides – Precursors of 3,3-Difluoroazetidinones.
Silver-Mediated C–H Difluoromethylation of Arenes.
One-pot synthesis of (ethoxycarbonyl)difluoromethylthioethers from thiocyanate sodium and ethyl 2-(trimethylsilyl)-2,2-difluoroacetate (TMS-CF2CO2Et).