2-(trimethylsilyl)-2,2-difluoride ethyl acetate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-Difluoro-2-(trimethylsilyl)acetic Acid Ethyl Ester,TMSCF2CO2Et
Difluoromethylating Reagents
KUMI2F42
205865-67-4
MFCD04973092
2758940
6385040
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
2-(trimethylsilyl)-2,2-difluoride ethyl acetate
C7H14F2O2Si
196.27
98%(GC)
Colorless to yellow Liquid
166°C
1ml,5ml,10ml,50ml,100ml and 500ml
Store at room temperature
2-(trimethylsilyl)-2,2-difluoride ethyl acetate(TMSCF2CO2Et) is used for a C–H difluoromethylation of arenes in an electrophilic radical substitution process. It can be also employed in an efficient and on-pot synthesis of (ethoxycarbonyl)difluoromethyl thioethers.
Ethyl Difluoro(trimethylsilyl)acetate and Difluoro(trimethylsilyl)acetamides – Precursors of 3,3-Difluoroazetidinones. [1]
Silver-Mediated C–H Difluoromethylation of Arenes. [2]
One-pot synthesis of (ethoxycarbonyl)difluoromethylthioethers from thiocyanate sodium and ethyl 2-(trimethylsilyl)-2,2-difluoroacetate (TMS-CF2CO2Et). [2]
References:
[1] M.Bordeau, F. Frébault, M.Gobet,J,-P,Picard, Eur.,J. Org. Chem., 2006, 18, pp 4147-4154.
[2] J.Li, W.Wan, G.Ma, Y.Chen, Q. Hu, K. Kang, H.Jiang, J. Hao,  Eur. J. Org. Chem., 2016, 28, pp 4916-4921.
[3] L.Xu, H.Wang, C. Zheng, G.Zhao, Tetrahedron, 2017, 73(42), pp 6057-6066.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226
P210,P233,P280,P303+P361+P353,P370+P378,P403+P235
2931.9000.90
UN 3272 3/PG II

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