1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Cabozantinib intermediate 2
API & Intermediates
KUMI1F78
849217-48-7
MFCD11226313
21081530
15712708
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid
C11H10FNO3
223.20
≥99%(HPLC)
White to Off-white Solid
167-170°C
5g,10g,25g,50g,100g and 500g
Store at 2-8°C
1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid is a pharmaceutical intermediate for the synthesis of Cabozantinib used to treat  medullary thyroid cancer and a second line treatment for renal cell carcinoma among others.
Discovery of 3H-imidazo[4,5-b]pyridines as potent c-Met kinase inhibitors: design, synthesis, and biological evaluation. [1]
Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2. [2]
Design, synthesis, and biological evaluation of thieno[2,3-d]pyrimidine derivatives as novel dual c-Met and VEGFR-2 kinase inhibitors. [3]
Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors. [4]
Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors. [5]
One-step synthesis of [18 F]cabozantinib for use in positron emission tomography imaging of c-Met. [6]
References:
[1] D.Chen, et al, ChemMedChem, 2012, 7(6), pp 1057-1070.
[2] H.Qiang, et al, Bioorg. Med. Chem., 2016, 24(16), pp 3353-3358.
[3] J.Li, et al, Bioorg. Med. Chem., 2017, 25(24), pp 6674-6679.
[4] D.Huang, et al, Eur. J. Med. Chem., 2017, 140, pp 212-228.
[5] Y.Zhao, et al, Bioorg. Med. Chem., 2017, 25(12), pp 3195-3205.
[6] V.T.Lien, et al, J. Labelled Comp. Radiopharm., 2018, 61(1), pp 11-17.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P264,P302+P352,P304+P340,P305+P351+P338,P332+P313,P337+P313

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Available on request.
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