1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid is a pharmaceutical intermediate for the synthesis of Cabozantinib used to treat medullary thyroid cancer and a second line treatment for renal cell carcinoma among others.
Discovery of 3H-imidazo[4,5-b]pyridines as potent c-Met kinase inhibitors: design, synthesis, and biological evaluation.
Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.
Design, synthesis, and biological evaluation of thieno[2,3-d]pyrimidine derivatives as novel dual c-Met and VEGFR-2 kinase inhibitors.
Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors.
Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.
One-step synthesis of [18 F]cabozantinib for use in positron emission tomography imaging of c-Met.
 D.Chen, et al, ChemMedChem, 2012, 7(6), pp 1057-1070.