2-(bromomethyl)-5-(trifluoromethyl)furan

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-(trifluoromethyl)furfuryl bromide
Trifluoromethyl Building Blocks, API&Intermediates
KUMI3F176
17515-77-4
MFCD03086219
2794605
11233814
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2-(bromomethyl)-5-(trifluoromethyl)furan
C6H4BrF3O
228.99
≥98%(GC)
Colorless to Pale yellow Liquid
161-166°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
2-(bromomethyl)-5-(trifluoromethyl)furan is a useful trifluoromethylated pharmaceutical intermediate, typically used for the preparation of tertiary sulfonamides as liver X receptor antagonists and hydantoin based inhibitors of MMP13 with potential use in osteoarthritis.
Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists. [1]
Hydantoin based inhibitors of MMP13--discovery of AZD6605. [2]
The First Asymmetric Pilot-Scale Synthesis of TV-45070. [3]
Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists. [4]
References:
[1] W.J.Zuercher, et al, J. Med. Chem., 2010, 53(8), pp 3412-3416.
[2] C. De Savi, et al, Bioorg. Med. Chem. Lett., 2013, 23(16), pp 4705-4712.
[3] J.A.Sclafani, et al, Org. Process Res. Dev., 2017, 21(10), pp 1616-1624.
[4] S.M.Kim, et al, Eur. J. Med. Chem., 2018, 145, pp 413-424.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302+H312+H332
P260,P280,P312
2906290090
UN 1760 8/PG III

1. Product Specification
2. Safety Data Sheet
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