4-fluoro-5-isopropyl-2-methoxyphenylboronic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(4-fluoro-2-methoxy-5-propan-2-ylphenyl)boronic acid
Fluorinated Building Blocks, API & Intermediates
KUMI1F134
875446-29-0
MFCD16294183
53363739
14512172
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-fluoro-5-isopropyl-2-methoxyphenylboronic acid
C10H14BFO3
212.03
≥98%
White to Off-white Solid
100-102°C
5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temp.
4-fluoro-5-isopropyl-2-methoxyphenylboronic acid is a fluorinated intermediate for the preparation of  cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.
Design of a novel class of biphenyl CETP inhibitors. [1]
Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib. [2]
SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors. [3]
References:
[1] Z.Lu, et al, Bioorg. Med. Chem. Lett., 2010, 20(24), pp 7469-7472.
[2] C.J.Smith, et al, J. Med. Chem., 2011, 54(3), pp 4880-4895.
[3] Z.Lu, et al, Bioorg. Med. Chem. Lett., 2012, 22(1), pp 199-203.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P271,P261,P280,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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