4-Hydroxy-6,7-dimethoxyqunioline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
6,7-dimethoxy-1H-quinolin-4-one, 6,7-dimethoxyquinolin-4-ol
API & Intermediates
KUMI0F66
13425-93-9
MFCD07368026
459611
160942
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
 4-Hydroxy-6,7-dimethoxyqunioline
C11H11NO3
205.21
≥98%(HPLC)
Slightly Pale Yellow to Yellow Solid
222-224°C
5g,10g,25g,50g,100g and 500g
Store at room temperature
 4-Hydroxy-6,7-dimethoxyqunioline is an important intermediate for the synthesis of various pharmaceuticals and radiopharmaceuticals, such as C-MET regulators, EGFR inhibitors, Tubulin Polymerization inhibitors, etc..
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. [1]
Identification of potent and selective inhibitors of PDGF receptor autophosphorylation. [2]
Formation of fluorine-18 labeled diaryl ureas--labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis. [3]
Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor. [4]
A New and Practical Synthesis of Tivozanib. [5]
Crystal structure of 6,7-dimeth-oxy-1-(4-nitro-phen-yl)quinolin-4(1H)-one: a mol-ecular scaffold for potential tubulin polymerization inhibitors. [6]
One-step synthesis of [18 F]cabozantinib for use in positron emission tomography imaging of c-Met. [7]
References:
[1] P.B.Madrid, et al, Bioorg. Med. Chem. Lett., 2005, 15(4), pp 1015-1018.
[2] T.Furuta, et al, J. Med. Chem., 2006, 49(7), pp 2186-2192.
[3] O.Ilovich, et al, Bioorg. Med. Chem., 2008, 16(8), pp 4242-4251.
[4] V.G.Pawar, et al, J. Med. Chem., 2010, 53(7), pp 2892-2901.
[5] C.P.Zhu, et al, Heterocycles, 2016, 92(10), pp 1882-1887.
[6] V.T.Lien, et al, Acta. Crystallogr. E. Crystallogr. Commun., 2017, 73(Pt.3). pp 441-444.
[7] V.T.Lien, et al, J. Labelled. Comp. Radiopharm., 2018, 61(1), pp
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods
H315,H319
P264,P280,P305+P351+P338
2933.49.7000
NONH for all modes of transport

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