4-Hydroxy-6,7-dimethoxyqunioline isan important intermediate for the synthesis of various pharmaceuticals and radiopharmaceuticals, such as C-MET regulators, EGFR inhibitors, Tubulin Polymerization inhibitors, etc..
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. 
Identification of potent and selective inhibitors of PDGF receptor autophosphorylation. 
Formation of fluorine-18 labeled diaryl ureas--labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis. 
Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.