4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan-3-yl]oxyquinazoline-4,6-diamine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Afatinib Impurity B, Afatinib metabolite M20
API & Intermediates
KUMI1F89
314771-76-1
MFCD18642925
15606392

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan-3-yl]oxyquinazoline-4,6-diamine
C18H16ClFN4O2
374.80
≥99%
Off-white to Light-yellow Solid
182-185°C
5g,10g,25g,50g,100g and 500g
Store at 2-8°C
4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan-3-yl]oxyquinazoline-4,6-diamine is a pharmaceutical intermediate for the synthesis of Afatinib used to treat non-small cell lung carcinoma (NSCLC).
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Available on request.
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