5-Fluorocytosine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Flucytosine, 5-FC, 4-Amino-5-fluoro-2-hydroxypyrimidine
API & Intermediates
KUMI1F129
2022-85-7
MFCD00006035
3366
3604562
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Fluorocytosine
C4H4FN3O
129.09
≥99%(HPLC)
White to Off-white Solid
298-300°C
5g,10g,25g,50g and 100g
-20°C Freezer
5-Fluorocytosine (also known as 5-FC, Fluorocytosine) is a nucleoside analog that has antifungal activies, typically used as an inhibitor of Nucleic Acid Synthesis of Fungi.  5-Fluorocytosine is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. It also inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.
Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. [1]
Current and future antifungal therapy: new targets for antifungal agents. [2]
Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. [3]
Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [4]
References:
[1] M.A.Ghannoum, et al, Clin. Microbiol. Rev., 1999, 12(4), pp 501-517.
[2] V.T.Andriole,  Int. J. Antimicrob. Agents, 2000, 16(3), pp 317-321.
[3] A.Vermes, et al, J. Antimicrob. Chemother., 2000, 46(2), pp 171-179.
[4] A.Loyse, et al, J. Antimicrob. Chemother., 2013, 68(11), pp 2435-2444.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H361
P281
2933599590
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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