5-fluorouracil

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Fluorouracil, 5-FU, 5-fluoro-1H-pyrimidine-2,4-dione
API & Intermediates
KUMI1F131
51-21-8
MFCD00006018
3385
127172
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-fluorouracil
C4H3FN2O2
130.08
≥99%(HPLC)
White Solid
282-286°C
5g,10g,25g,50g and 100g
Store at 2-8°C temperature
5-fluorouracil (also known as Fluorouracil, 5-FU) is an Antitumor Antimetabolite with Activity against Numerous Types of Neoplasms. It is also used as reagent for gastropathy (gastric mucosal injury) model and nausea or vomiting model.
Fluorouracil: biochemistry and pharmacology. [1]
5-fluorouracil: mechanisms of action and clinical strategies. [2]
The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential. [3]
Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis. [4]
A review of analytical methods for the determination of 5-fluorouracil in biological matrice. [5]
References:
[1] H.M.Pinedo, et al, J. Clin. Oncol., 1988, 6(10), pp 1653-1664.
[2] D.B.Longley, et al, Nat. Rev. Cancer, 2003, 3(5), pp 330-338.
[3] K.Yamamoto, et al, Eur. J. Pharmacol., 2007, 554(1), pp 34-39.
[4] Y.Saequsa, et al, Scand. J. Gastroenterol., 2008, 43(5), pp 531-537.
[5] M.Breda, et al, Anal. Bioanal. Chem., 2010, 397(3), pp 1191-1201.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H361
P281
2933599590
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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