6α,9-difluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
6-alpha-Fluoro-isoflupredone, 6α,​9α-​Difluoroprednisolone, NSC 77021
API & Intermediates
KAPI2F08
806-29-1
MFCD09263627
101859
3176679
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
6α,9-difluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione
C21H26F2O5
396.42
≥98%(HPLC)
White to Pale Beige Solid
250-257°C
500mg,1g,10g,25g,50g,100g,500g and 1kg
2-8°C Refrigerator
6-alpha-Fluoro-isoflupredone (also known as 6α,​9α-​Difluoroprednisolone, NSC 77021) is a corticosteroid hormone. It has been used as therapeutic steroid for the management of certain diseases of the eye. In more recent screens for anti-cancer activity 6-alpha-Fluoro-isoflupredone proved active in the NCI human tumor cell line growth inhibition assay.
Relation of glucocorticoid activity of steroids to number of metastases. [1]
Synthesis and topical antiinflammatory properties of 17,21-bis(acetyloxy)-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione and related 2-halogenated compounds. [2]
Structure-activity relationships in the antiinflammatory steroids: a pattern-recognition approach. [3]
Computer-aided studies of the structure-activity relationships between the structure of some steroids and their antiinflammatory activity. [4]
Optimization of Potent Hepatitis C Virus NS3 Helicase Inhibitors Isolated from the Yellow Dyes Thioflavine S and Primuline. [5]
References:
[1] D.Albert, et al, Cancer Res., 1962, 22, pp 1297-1300.
[2] L.Toscano, et al, J. Med. Chem., 1977, 20(2), pp 213-220.
[3] N.Bodor, et al, J. Med. Chem., 1983, 26(3), pp 318-328.
[4] T.R.Stouch, et al, J. Med. Chem., 1986, 29(11), pp 2125-2136.
[5] K.Li, et al, J. Med. Chem., 2012, 55(7), pp 3319-3330.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H351
P281
2937220000
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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