7-Fluoro-6-nitro-4-hydroxyquinazoline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
7-Fluoro-6-nitroquinazolin-4(3H)-one
API & Intermediates
KUMI1F91
162012-69-3
MFCD08458874
7063911
7481719
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
7-Fluoro-6-nitro-4-hydroxyquinazoline
C8H4FN3O3
209.14
≥99%
Yellow Solid
283-285°C
5g,10g,25g,50g,100g and 500g
Store at 2-8°C
7-Fluoro-6-nitro-4-hydroxyquinazoline is a pharmaceutical intermediate for the synthesis of kinase inhibitors, such as ATP Site inhibitors of the Tyrosine Kinase activity of the epidermal growth factor receptor.
Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor. [1]
Structure-based virtual screening of Src kinase inhibitors. [2]
Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor-Based Spin Labeling. [3]
References:
[1] G.W.Rewcastle, et al, J. Med. Chem., 1996, 39(4), pp 918-928.
[2] K.Lee, et al, Bioorg. Med. Chem., 2009, 17(8), pp 3152-3161.
[3] D.M.Yin, et al, Angew. Chem. Int. Ed. Engl., 2017, 56(29), pp 8417-8421.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H332,H335
P264,P280,P302+P352,P304+P340,P305+P351+P338,P332+P313,P337+P313

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Available on request.
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