8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef]benzazepin-6-one is a pharmaceutical intermediate for the synthesis of poly-ADP ribose polymerase-1(PARP-1) inhibitors, e.g. Rucaparib, used as an anti-cancer agent.
Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor.
Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation.
Patent Review of Manufacturing Routes to Recently Approved PARP Inhibitors: Olaparib, Rucaparib, and Niraparib.
 A.T.Gillmore, et al, Org. Process Res. Dev., 2012, 16(12), pp 1897-1904.