ABT 199

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GDC 0199, Venetoclax
API & Intermediates
KAPI0F25
1257044-40-8
MFCD23160052
49846579
20908256
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
ABT 199
C45H50ClN7O7S
868.45
≥99%(HPLC)
White to Yellow Solid
141-146°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
ABT 199 (also known as GDC 0199, Venetoclax) is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It is typically used to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
ABT-199: A New Hope for Selective BCL-2 Inhibition. [1]
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. [2]
ABT‐199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. [3]
Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition. [4]
References:
[1] M.S.Davids, et al, Cancer Cell, 2013, 23(2), pp 139-141.
[2] A.J.Souers, et al, Nat. Med., 2013, 19(2), pp 202-208.
[3] M.Vogler, et al, Brit. J. Haematol., 2013, 163(1), pp 139-142.
[4] H.Tamaki, et al, Oncotarget., 2014, 5(22), pp 11399-11412.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H361,H372
P201,P202,P260,P264,P280,P308+P313,P314

NONH for all modes of transport
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1. Product Specification
2. Safety Data Sheet
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