Alverine citrate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-Ethyl-3,3′-diphenyldipropylamine, NSC 35459
API & Intermediates
KAPI0F32
5560-59-8
MFCD00035086
21718
3851428
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay by HCLO4(Titration)
Appearance
Melting Point
Packaging
Storage
Alverine citrate
C26H35NO7
473.56
≥99%
White to Almost white Solid
100-101°C
5g,10g,25g,50g,100g and 500g
Store at room temperature
Alverine citrate is typically used to relieve cramps or spasms of the stomach and intestines. It also has other pharamceutical applications, e.g. treat irritable bowel syndrome (IBS) and similar conditions, relieve period pain and  increase the cytotoxic effects of the proteasome inhibitor MG132 on breast cancer cells.
Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. [1]
Evolving mechanisms of action of alverine citrate on phasic smooth muscles. [2]
Anxiolytic-like effects of alverine citrate in experimental mouse models of anxiety. [3]
Anodic adsorptive stripping voltammetric determination of alverine citrate in its pharmaceutical formulation. [4]
An improved LC-MS/MS method for the quantification of alverine and para hydroxy alverine in human plasma for a bioequivalence study. [5]
References:
[1] A.M.Coelho, et al, J. Pharm. Pharmacol., 2001, 53(10), pp 1419-1426.
[2] M.Hayase, et al, Br. J. Pharmacol., 2007, 152(8), pp 1228-1238.
[3] D.Gupta. et al, Eur. J. Pharmacol., 2014, 742, pp 94-101.
[4] S.I.M. Zayed, et al, Int. J. Electrochem. Sci., 2016, 11(3), pp 2317-2325.
[5] D.M.Rathod, et al, J. Pharm. Anal., 2017, 7(2), pp 95-102.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods


29214900900
NONH for all modes of transport

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