Aprepitant 

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Emend, MK-869, MK-0869, Aprepitantum
API & Intermediates
KAPI7F01
170729-80-3
MFCD12912491
6918365
8096869
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Aprepitant 
C23H21F7N4O3
534.43
≥98% (HPLC)
White to Pale Beige Solid
244-245°C
5g,10g,25g,50g,100g,250g and 500g
Store at 2-8°C temp.
Aprepitant is a potent and selective antagonist of human substance P/neurokinin 1 (NK1) receptors used clinically to treat chemotherapy-induced or post-operative nausea and vomiting, and being investigated for other activity including possible treatment for depression and pruritis. 
Aprepitant: a neurokinin-1 receptor antagonist for the treatment of chemotherapy-induced nausea and vomiting. [1]
Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives. [2]
Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK1/NK3 antagonists. [3]
References:
[1] R.M.Navari, Expert Rev. Anticancer Ther., 2004, 4(5), pp 715-724.
[2] L.C.Meurer, et al, Bioorg. Med. Chem. Lett., 2006, 16(17), pp 4504-4511.
[3] C.Bissantz,  et al, J. Med. Chem., 2012, 55(11), pp 5061-5076.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Not classified as a hazardous substance or mixture


2934999090
NONH for all modes of transport


1. Product Specification
2. Safety Data Sheet
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