Ataluren

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
PTC124, 3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid
Fluorinated Building Blocks, API&Intermediates
KAPI1F17
775304-57-9
MFCD09864996
11219835
11233814
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ataluren
C15H9FN2O3
286.24
≥99%
White Solid
241-242°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid (also known as Ataluren, PTC124) is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins. It also empoyed as a potent inhibitor of firefly luciferase (FLuc).
PTC124 targets genetic disorders caused by nonsense mutations. [1]
PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model. [2]
Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124). [3]
Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis. [4]
A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays. [5]
References:
[1] E.M.Welch, et al, Nature, 2007, 447(7140), pp 87-91.
[2] M.Du, et al, Proc. Natl. Acad. Sci. U.S.A., 2008, 105(6), pp 2064-2069.
[3] R.S. Finkel, et al, J. Child Neurol., 2010, 25(9), pp 1158-1164.
[4] M.Wilschanski, et al, Eur. Respir. J., 2011, 38(1), pp 59-69.
[5] S.P.McElroy, et al, PLOS Biology, 2013, 11(6), pp 1-8.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H317,H335
P264,P280,P362+P364,P261,P272

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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