BIBF1120

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Nintedanib, Vargatef, BIBF-1120, Intedanib
API & Intermediates
KAPI0F12
928326-83-4
MFCD11974012
9809715

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
BIBF1120
C31H33N5O4
539.62
≥99.8%(HPLC)
Bright Yellow Solid

500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
BIBF1120 (also known as Nintedanib, Vargatef, BIBF-1120, Intedanib) is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR). It is typcially used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. [1]
An Open-label Dose-escalation Study of BIBF 1120 in Patients with Relapsed or Refractory Multiple Myeloma. [2]
A randomized phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer (OC). [3]
A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies. [4]
Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors. [5]
Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients. [6]
Nintedanib: a novel therapeutic approach for idiopathic pulmonary fibrosis. [7]
Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer: a network meta-analysis. [8]
Nintedanib in the treatment of idiopathic pulmonary fibrosis. [9]
Nintedanib in patients with idiopathic pulmonary fibrosis: Combined evidence from the TOMORROW and INPULSIS® trials. [10]
Clinical use of nintedanib in patients with idiopathic pulmonary fibrosis. [11]
References:
[1] F.Hillberg, et al, Cancer Res., 2008, 68(12), pp 4774-4782.
[2] M.Kropff, et al, Anticancer Res., 2009, 29(10), pp 4233-4238.
[3] J.A.Ledermann, et al, J. Clin. Oncol., 2009, 27(15s), pp 5501-5501.
[4] A.du Bois, et al, Ann. Oncol., 2010, 21(2), pp 370-375.
[5] K.Mross, et al, Clin. Cancer Res., 2010, 16(1), pp 311-319.
[6] P.M.Ellis, et al, Clin. Cancer Res., 2010, 16(10), pp 2881-2889.
[7] I.A.Dimitroulis, et al, Respir. Care., 2014, 59(9), pp 1450-1455.
[8] S.Popat, et al, Future Oncol., 2015, 11(3), pp 409-420.
[9] M.E.Mazzei, et al, Ther. Adv. Respir. Dis., 2015, 9(3), pp 121-129.
[10] L.Richeldi, et al, Respir. Med., 2016, 113, pp 74-79.
[11] A.Hajari Case ,et al, BMJ Open Resp. Res., 2017, 4(1), e000192.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



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