BIBF1120 (also known as Nintedanib, Vargatef, BIBF-1120, Intedanib) is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR). It is typcially used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
An Open-label Dose-escalation Study of BIBF 1120 in Patients with Relapsed or Refractory Multiple Myeloma.
A randomized phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer (OC).
A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies.
Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors.
Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients.
Nintedanib: a novel therapeutic approach for idiopathic pulmonary fibrosis.
Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer: a network meta-analysis.
Nintedanib in the treatment of idiopathic pulmonary fibrosis.
Nintedanib in patients with idiopathic pulmonary fibrosis: Combined evidence from the TOMORROW and INPULSIS® trials.
Clinical use of nintedanib in patients with idiopathic pulmonary fibrosis.
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