Ceritinib

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Ceritinib free base, LDK 378, Zykadia
API & Intermediates
KAPI0F23
1032900-25-6
MFCD26142648
57379345
18383989
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ceritinib
C28H36ClN5O3S
558.14
≥99%(HPLC)
White Solid
162°C
500mg,1g,2g,5g,10g,25g,50g,100g and 500g
-20°C Freezer
Ceritinib (also known as LDK 378, Zykadia) is an anaplastic lymphoma kinase (ALK)-positive inhibitor primarily used for the treatment of metastatic non-small cell lung cancer (NSCLC).
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials. [1]
ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. [2]
Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK. [3]
ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. [4]
References:
[1] T.H.Marsilje, et al, J. Med. Chem., 2013, 56(14), pp 5675-5690.
[2] M.M.Awad, et al, Clin. Adv. Hematol. Oncol., 2014, 12(7), pp 429-439.
[3] D.Fontana, et al, Cancer Med., 2015, 4(7), pp 953-965.
[4] I.Sullivan, et al, Ther. Adv. Med. Oncol., 2016, 8(1), pp 32-47.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



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