Cinepazide maleate (1-(Pyrrolidinyl-1-carbonyl)-methyl-4-(3,4,5-trimethoxycinnamoyl)-piperazine-maleate) is a vasodilator agent used clinically in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. Cinepazide maleate is thought to act as a potentiator of adenosine A2 receptors and has also been characterized as a calcium channel blocker. It was withdrawn for agranulocytosis in several countries.
Effect of vasodilators on hepatic microcirculation: a study of the inhibition of norepinephrine-induced vasoconstriction in the isolated perfused rat liver.[1]
Determination of cinepazide maleate in rat plasma by LLE Using LC-MS-MS.[2]
High performance liquid chromatographic method for the determination of cinepazide maleate and its application to a pharmacokinetic study in rats.[3]
References:
[1] P.Marteau, et al, Hepatology, 1988, 8(2), pp 228-231.
[2] G.Lin, et al, Chromatographia, 2010, 72(7-8), pp 737-741.
[3] J. Zhao, et al, J. Chromatogr. B, 2014, 957, pp 105-109.
