CO-1686

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Rociletinib, AVL-301, CNX-419
API & Intermediates
KAPI3F04
1374640-70-6
MFCD26793864
57335384
23999130
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
CO-1686
C27H28F3N7O3
555.56
≥99%(HPLC)
White to Off-white Solid
202-205°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
CO-1686 (also known as Rociletinib, AVL-301, CNX-419) is an irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of Epidermal Growth Factor Receptor(EGFR), including T790M, while exhibiting minimal activity toward the wild-type (WT) receptor.
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. [1]
Reference:
[1] A.Q.Walter, et al, Cancer discov., 2013, 3(12), pp 1404-1415.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a dangerous goods



NONH for all modes of transport
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