Dutasteride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Avodart, Avolve, GG-745, veltride, Duagen
API & Intermediates
KAPI6F02
164656-23-9
MFCD00937869
6918296

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Dutasteride
C27H30F6N2O2
528.53
≥98% (HPLC)
White to Off-white Solid
241-243°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at 2-8°C temp.
Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride. It is primarily used in the treatment of benign prostatic hyperplasia.
17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1. [1]
Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. [2]
Pharmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteridedesonide 0.05%: a clinical safety profile. [3]
Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer. [4]
Controlled release of dutasteride from biodegradable microspheres: in vitro and in vivo studies. [5]
References:
[1] G.Tian, et al, Biochemistry, 1994, 33(8), pp 2291-2296.
[2] H.N.Bramson, et al, J. Pharmacol. Exp. Ther., 1997, 282(3), pp 1496-1502.
[3] N.Makridakis, et al, J. Mol. Endocrinol., 2005, 34(3), pp 617-623.
[4] T.C.Shao, et al, J. Urol., 2007, 178(4 Pt 1), pp 1521-1527.
[5] X.Xie, et al, pLos One, 2014, 9(12):e114835.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Not a dangerous goods


2937290000
NONH for all modes of transport

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