Ezetimibe (also known as Ezetrol, SCH 58235) is a cholesterol absorption inhibitor for lowering plasma cholesterol levels. It inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.
Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663.[1]
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).[2]
Regulation of intestinal cholesterol absorption.[3]
