Ezetimibe

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Ezetrol, SCH 58235
API & Intermediates
KAPI2F09
163222-33-1
MFCD00937872
150311
7981967
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ezetimibe
C24H21F2NO3
409.43
≥99%(HPLC)
White Solid
164-166°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Ezetimibe (also known as Ezetrol, SCH 58235) is a cholesterol absorption inhibitor for lowering plasma cholesterol levels. It inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.
Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. [1]
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). [2]
Regulation of intestinal cholesterol absorption. [3]
Ezetimibe and vascular endothelial function. [4]
References:
[1] M.Van Heek, et al, Br. Pharmacol., 2000, 129(8), pp 1748-1754.
[2] M.Garcia-calvo, et al, Proc. Natl. Acad. Sci. USA, 2005, 102(23), pp 8132-8137.
[3] D.Q.Wang, Annu. Rev. Physiol., 2007, 69, pp 221-248.
[4] S.Ikeda, et al, Curr. Vasc. Pharmacol., 2011, 9(11), pp 87-98.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H332,H302,H312,H315,H319,H335
P261,P264,P280,P304+P340,P301+P312,P321,P305+P351+P338

NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
2. Safety Data Sheet
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