Famciclovir

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester
API & Intermediates
KAPI0F11
104227-87-4
MFCD00866964
3324
4208403
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Famciclovir
C14H19N5O4
321.34
≥98%(HPLC)
White Solid
102-103°C
100mg,500mg,1g,5g,10g,20g,50g,100g,500g and 1kg
-20°C Freezer
Famciclovir (also known as BRL 42810 ) is an antiretroviral guanosine analog used for the treatment of  various herpesvirus infections, most commonly for herpes zoster(shingles). It is a prodrug form of penciclovir with improved oral bioavailability.
In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. [1]
Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. [2]
In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance. [3]
References:
[1] M.R.Rashidi, et al, Drug Metab. Dispos, 1997, 25(7), pp 805-813.
[2] M.Melegari, et al, Hepatology, 1998, 27(2), pp 628-633.
[3] X.Xiong, et al, Hepatology, 2000, 31(1), pp 219-224.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a dangerous goods


29335995900
NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
For further information and support on USP Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by USP can be found here.
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