Fasudil hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
5-(1-Homopiperazinyl)sulfonylisoquinoline hydrochloride
API & Intermediates
KAPI0F41
105628-07-7
MFCD00943198
160871255
5466340
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Fasudil hydrochloride
C14H17N3O2S•HCl
327.83
≥98% (HPLC)
White to Off-white Solid
222°C
5g,10g,25g,50g,100g,250g and 500g
Store at 2-8°C temp.
Fasudil hydrochloride is a cell-permeable, selective ROCK inhibitor potent Rho-kinase inhibitor and vasodilator. it has been used for the treatment of cerebral vasospasm and pulmonary hypertension.
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. [1]
Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. [2]
A ROCK inhibitor permits survival of dissociated human embryonic stem cells. [3]
References:
[1] H.Hidaka, et al, Biochemistry, 1984, 23(21), pp 5036-5041.
[2] H.Nagumo, et al, Am. J. Physiol. Cell Physiol., 2000, 278(1), pp C57-C65.
[3] K.Watanabe, et al, Nat. Biotechnol., 2007, 25(6), pp 681-686.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Warning
H302
P264,P270,P301+P312+P330,P501
2935909099
NONH for all modes of transport


1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.