3-amino-N-(4-fluorophenyl)-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
FDI 6, NCGC00099374
API & Intermediates
KUMI4F29
313380-27-7
MFCD01416826
5175738

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-amino-N-(4-fluorophenyl)-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide
C19H11F4N3OS2
437.43
≥98%(HPLC)
White to Beige Solid

50mg,100mg,200mg,500mg,1g,2g,5g and 10g
Store at 2-8°C
FDI 6 (also known as NCGC00099374) is a potent and specific inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) that blocks DNA binding. It displaces ​FOXM1 from genomic targets in MCF-7 breast cancer cells, and downregulates concomitant transcription.
Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. [1]
Is there potential to target FOXM1 for 'undruggable' lung cancers? [2]
[Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1]. [3]
Untying the knot of transcription factor druggability: Molecular modeling study of FOXM1 inhibitors. [4]
References:
[1] M.V. Gormally, et al, Nat. Commun., 2014, Nov. 12, 5:5165.
[2] V.V.Kalinichenko, et al, Expert. Opin. Ther. Targets, 2015, 19(7), pp 865-867.
[3] Y.Lin, et al, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017, 33(5), pp 611-616.
[4] S.A.Tabatabaei-Dakhili, et al, J. Mol. Graph. Model, 2018, 80, pp 192-210.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture


2934999090
NONH for all modes of transport

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