Finasteride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide
API & Intermediates
KAPI0F35
98319-26-7
MFCD00869737
6918296
4269024
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Finasteride
C23H36N2O2
372.55
≥98% (HPLC)
White to Off-white Solid
252-254°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at 2-8°C temp.
Finasteride is the first selective type2 5α-reductase inhibitor, which blocks the conversion of testosterone  to 5α-dihydrotestosterone (DHT) in target organs such as the prostate and scalp hair. It also has been studied for its ability to reduce the incidence of prostate cancer.
Finasteride: an update of its use in the management of symptomatic benign prostatic hyperplasia. [1]
Finasteride: a review of its use in male pattern hair loss. [2]
A new look at the 5alpha-reductase inhibitor finasteride. [3]
The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer. [4]
Type 1 and type 2 5alpha-reductase expression in the development and progression of prostate cancer. [5]
An overview on 5alpha-reductase inhibitors. [6]
Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. [7]
References:
[1] M. I. Wilde, et al, Drugs, 1999, 57(4), pp 557-581.
[2] K. J. McClellan, et al, Drugs, 1999, 57(1), pp 111-126.
[3] D. A. Finn, et al, CNS Drug Rev., 2006, 12(1), pp 53-76.
[4] D. J. Tindall, et al, J. Urol., 2008, 179(4), pp 1235-1242.
[5] L. N. Thomas, et al, Eur. Urol., 2008, 53(2), pp 244-252.
[6] S. Aggarwal, et al, Steroids, 2010, 75(2), pp 109-153.
[7] D. K. Yun, et al, Biomol. Ther. (Seoul), 2013, 21(1), pp 49-53.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Warning
H302

2937290000
NONH for all modes of transport
CL5245000

1. Product Specification
2. Safety Data Sheet
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