Flumethasone (also known as Flumethasone, Fluorodexamethasone) is a synthetic ant-inflammatory glucocorticoid and corticosteroid used as one of the most potent glucocorticoid receptor agonist. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Effect of steroidal anti-inflammatory drugs on Escherichia coli endotoxin-induced mastitis in the cow.
The effect of steroidal and non-steroidal anti-inflammatory drugs on the cellular immunity of calves with experimentally-induced local lung inflammation.
Determination of flumethasone in calf urine and serum by liquid chromatography-tandem mass spectrometry.
Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia.
Lack of effect of metyrapone and exogenous cortisol on early porcine conceptus development.
Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish.
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