GW3965 hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GW3965 HCl
API & Intermediates
KUMI3F160
405911-17-3
MFCD08276920
16078973

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
GW3965 hydrochloride
C33H32Cl2F3NO3
618.52
≥98%(HPLC)
White Solid

50mg,100mg,200mg,500mg,1g,2g and 5g
Store at 2-8°C
GW3965 hydrochloride is a synthetic liver X receptor (LXR) agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR).
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. [1]
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. [2]
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. [3]
LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice. [4]
Action mechanisms of Liver X Receptors. [5]
References:
[1] J.L.Collins, et al, J. Med. Chem., 2002, 45(10), pp 1963-1966.
[2] S.B.Joseph, et al, Nat. Med., 2003, 9(2), pp 213-219.
[3] C.E.Leik, et al, Br. J. Pharmacol., 2007, 151(4), pp 450-456.
[4] A.Archer, et al, J. Lipid Res., 2013, 54(5), pp 1300-1311.
[5] C.Gabbi, et al, Biochem. Biophys. Res. Commun., 2014, 446(3), pp 647-650.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302,H318,H413
P280,P305+P351+P338
2922190090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Available on request.
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.