2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-acetic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GW501516, GW 1516
API & Intermediates
KAPI3F02
317318-70-0
MFCD09033000
9803963
18515150
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-acetic acid
C21H18F3NO3S2
453.51
≥98%(HPLC)
White to Off-white Solid
133-134°C
500mg,1g,5g,10g,50g,100g,500g and 1kg
2-8°C Refrigerator
GW501516 (also named as GW 1516) is an experimental drug, which can act like a peroxisome proliferator-activated receptor agonist, to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. It can play an important role in the regulation of central inflammation and can also be used to control brain inflammation process.
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. [1]
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. [2]
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. [3]
Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination. [4]
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation. [5]
References:
[1] W.R.Oliver, et al, Proc. Natl. Acad. Sci. USA, 2001, 98(9), pp 5306-5311.
[2] M.L.Sznaidaman, et al, Bioorg. Med. Chem. Lett., 2003, 13(9), pp 1517-1521.
[3] Y.X.Wang, et al, Cell, 2003, 113(2), pp 159-170.
[4] A.Defaux, et al, J. Neuroinflammation, 2009, 6, pp 15-27.
[5] R.Bosviel, et al, Free Radic. Biol. Med., 2017, 103, pp 146-154.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture


2934100090
NONH for all modes of transport

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