Ibandronate sodium monohydrate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Ibandronate monosodium salt monohydrate, BM-21.0955, Bondronat
API & Intermediates
KAPI0F10
138926-19-9
MFCD00912167
23663991
11327959
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ibandronate sodium monohydrate
C₉H₂₄NNaO₈P₂
359.23
≥99%
White Solid
176-184°C
10g,20g,50g,100g,500g,1kg and 5kg
-20°C Freezer
Ibandronate sodium monohydrate (BM-21.0955, Bondronat) is a potent bisphosphonate drug and bone resorption inhibitor for the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in the people with cancer.  It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
BM 21.0955, a potent new bisphosphonate to inhibit bone resorption. [1]
Randomized phase II trial comparing different doses of the bisphosphonate ibandronate in the treatment of hypercalcemia of malignancy. [2]
Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update From the American College of Physicians. [3]
Breast cancer bone metastases: pathogenesis and therapeutic targets. [4]
References:
[1] R.C.Muhlbauer, et al, J. Bone Miner. Res., 1991, 6(9), pp 1003-1011.
[2] M.Pecherstorfer, et al, J. Clin. Oncol., 1996, 14(1), pp 268-276.
[3] A.Qaseem, et al, Ann. Intern. Med., 2017, 166(11), pp 818-839.
[4] N.Brook, et al, Int. J. Biochem. Cell Biol., 2018, 96, pp 63-78.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P305+P351+P338
2931399090
UN 1759 8 / PGIII
Sales restrictions may apply.
1. Product Specification
For further information and support on USP Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by USP can be found here.
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