Ibandronate sodium

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
Ibandronic acid monosodium salt, Bondronat
API & Intermediates
KAPI0F09
138844-81-2
MFCD07197214
329815388
14511791
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ibandronate sodium
C9H22NNaO7P2
341.21
≥97%(NMR)
White Solid
202-206°C
10g,20g,50g,100g,500g,1kg and 5kg
Store at 2-8°C temperature (protect from light)
Ibandronate sodium (Ibandronic acid monosodium salt, Bondronat) is a potent bisphosphonate drug and bone resorption inhibitor for the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in the people with cancer.  It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
Nitrogen‐Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post‐Translational Prenylation of GTP‐Binding Proteins, Including Ras. [1]
Etidronate (EHDP) Inhibits Osteoclastic-Bone Resorption, Promotes Apoptosis and Disrupts Actin Rings in Isolate-Mature Osteoclasts. [2]
Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates. [3]
Bisphosphonates Inhibit Angiogenesis in Vitro and Testosterone-stimulated Vascular Regrowth in the Ventral Prostate in Castrated Rats. [4]
Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. [5]
References:
[1] S.P.Luckman, et al, J. Bone Miner. Res., 1998, 13(4), pp 581-589.
[2] E.Hiroi-Furuya, et al, Calcif. Tissue Int., 1999, 64(3), pp 219-223.
[3] J.E.Dunford, et al, J. Pharmacol. Exp. Ther., 2001, 296(2), pp 235-242.
[4] P.Fournier, et al, Cancer Res., 2002, 62(22), pp 6538-6544.
[5] R.G.G.Russell, et al, Osteoporos. Int., 2008, 19(6), pp 733-759.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture


2931399090
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