Ledipasvir

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GS-5885, GS5885, GS 5885
API & Intermediates
KAPI2F01
1256388-51-8
MFCD25976756
67505836
23926149
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ledipasvir
C49H54F2N8O6
889.02
≥98%(HPLC)
White to Pale-beige Solid
168-172°C
100mg,500mg,1g,5g,10g,20g,50g,100g,500g and 1kg
-20°C Freezer
Ledipasvir (formally labeled as GS-5885, GS5885, GS 5885) is an inhibitor of non-structural protein 5A of hepatitis C virus, most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly and secretion.
A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C. [1]
NS5A inhibitors in the treatment of hepatitis C. [2]
Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection. [3]
Preclinical Characterization of the Novel Hepatitis C Virus NS3 Protease Inhibitor GS-9451. [4]
References:
[1] E.J.Lawitz, et al, J. Hepatol., 2012, 57(1), pp 24-31.
[2] J.M.Pawlotsky, et al, J. Hepatol., 2013, 59(2), pp 375-385.
[3] N.Afdhal, et al, N. Engl. J. Med., 2014, 370, pp 1889-1898.
[4] H.Yang, et al, Antimicrob. Agents Chemother., 2014, 58(2), pp 647-653.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P264,P280,P305+P351+P338
293490
NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
For further information and support on Ph. Eur. Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by EDQM can be found here.
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