Lenvatinib mesylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Lenvatinib methanesulfonate, E7080 mesylate
API & Intermediates
KAPI0F16
857890-39-2
MFCD18633219
11237762
14616854
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Lenvatinib mesylate
C21H19ClN4O4CH4O3S
522.96
≥99.8%(HPLC)
Off-white Solid
228-230°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Lenvatinib mesylate (also known as Lenvatinib methanesulfonate, E7080 mesylate) is the methanesulfonate salt form of Lenvatinib(E7080), which is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors used for the treatment of certain kinds of thyroid cancer, and potentially for other cancers as well.
E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. [1]
Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. [2]
Multikinase inhibitors: a new option for the treatment of thyroid cancer. [3]
References:
[1] J.Matsui, et al, Int. J. Cancer, 2008, 122(3), pp 664-671.
[2] J.Matusui, et al, Clin. Cancer Res., 2008, 14(17), pp 5459-5465.
[3] M.L.Gild, et al, Nature Rev. Endocrinol., 2011, 7, pp 617-624.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods


2933998090
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