2-[[5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Lesinurad, RDEA594
API & Intermediates
KAPI0F14
878672-00-5
MFCD22572730
53465279

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-[[5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid
C17H14BrN3O2S
404.28
≥99.8%(HPLC)
White Solid
>171°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Lesinurad (also known as RDEA594) is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. It is used in combination with a xanthine oxidase inhibitor, such as allopurinol, for treating hyperuricemia (high levels of uric acid in the blood serum) associated with gout.
Gout therapeutics: new drugs for an old disease. [1]
Mechanism of high affinity inhibition of the human urate transporter URAT1. [2]
Identification and characterization of a potent and selective inhibitor of human urate transporter 1. [3]
References:
[1] C.M. Burns, et al, Lancet., 2011, 377(9760), pp 165-177.
[2] P.K.Tan,et al, Sci. Rep., 2016, 6, pp 34995: 1-13.
[3] T.Wu, et al, Pharmacol. Rep., 2017, 69(5), pp 1103-1112.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods


2933998090
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