2-[[5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid

Synonym

Product Category

Product Code

CAS Number

MDL Number

Pubchem CID

Reaxys RN

Lesinurad, RDEA594

API & Intermediates

KAPI0F14

878672-00-5

MFCD22572730

53465279

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png

Specification
Applications
Safety & Regulations
Product Documents

Chemical Name

Molecular Formula

Molecular Weight

Assay

Appearance

Melting Point

Packaging

Storage

2-[[5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid

C₁₇H₁₄BrN₃O₂S

404.28

≥99.8%(HPLC)

White Solid

>171°C

500mg,1g,10g,25g,50g,100g and 500g

-20°C Freezer

Lesinurad (also known as RDEA594) is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. It is used in combination with a xanthine oxidase inhibitor, such as allopurinol, for treating hyperuricemia (high levels of uric acid in the blood serum) associated with gout.

Gout therapeutics: new drugs for an old disease. [1]

Mechanism of high affinity inhibition of the human urate transporter URAT1. [2]

Identification and characterization of a potent and selective inhibitor of human urate transporter 1. [3]

References:

[1] C.M. Burns, et al, Lancet., 2011, 377(9760), pp 165-177.

[2] P.K.Tan,et al, Sci. Rep., 2016, 6, pp 34995: 1-13.

[3] T.Wu, et al, Pharmacol. Rep., 2017, 69(5), pp 1103-1112.

Signal Word

Hazard Statements

Precautionary Statements

HS Code

RIDADR

Legal Information

Not classified as a dangerous goods

2933998090

NONH for all modes of transport

Sales restrictions may apply.

1. Product Specification

Product Specification_Lesinurad

2. Safety Data Sheet

Available on request.

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