N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Linezolid, PNU-100766, U-100766
API & Intermediates
KAPI1F04
165800-03-3
MFCD00937825
441401
7496939
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide
C16H20FN3O4
337.35
≥98%
White Solid
178-179°C
500mg,1g,5g,10g,50g,100g,500g and 1kg
-20°C Freezer
Linezolid(also known as PNU-100766, U-100766) is a prototype of the oxazolidinone antimicrobials against a wide range of Gram-positive bacteria, including resistant strains of several species, such as MRSA, penicillin-resistant pneumococci, vancomycin-resistant enterococci, many different streptococci, various anaerobic bacteria, and several mycobacteria. It binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.
Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections. [1]
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. [2]
Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections. [3]
Clinical update on linezolid in the treatment of Gram-positive bacterial infections. [4]
References:
[1] S.J.Brickner, et al, J. Med. Chem., 1996, 39(3), pp 673-679.
[2] C.W.Ford, et al, Antimicrob. Agents Chemother., 1996, 40(6), pp 1508-1513.
[3] D.L.Stevens, et al, Clin. Infect. Dis., 2002, 34(11), pp 1481-1490.
[4] S.Ager, et al, Infect. Drug Resist., 2012, 5, pp 87-102.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H372
P260
2933998090
NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
For further information and support on USP Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by USP can be found here.
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