Loteprednol etabonate

Synonym

Product Category

Product Code

CAS Number

MDL Number

Pubchem SID

Reaxys RN

CDDD 5604, HGP 1, P 5604

API & Intermediates

KAPI0F06

82034-46-6

MFCD00870765

329825544

5461012

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png

Specification
Applications
Safety & Regulations
Product Documents

Chemical Name

Molecular Formula

Molecular Weight

Assay

Appearance

Melting Point

Packaging

Storage

Loteprednol etabonate

C₂₄H₃₁ClO₇

466.95

≥98%(HPLC)

White to Beige Solid

220-223°C

10g,20g,50g,100g,500g,1kg and 5kg

-20°C Freezer

Loteprednol etabonate ((11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-Androsta-1,4-diene-17-carboxylic acid chloromethyl ester) is a "soft" steroid, typically used in topical applications for inflammatory conditions of the eye. It is an agonist of both glucocorticoid and mineralcorticoid receptors.

Loteprednol etabonate: a review of ophthalmic clinical studies. [1]

Topical loteprednol pretreatment reduces cyclosporine stinging in chronic dry eye disease. [2]

Efficacy and safety of loteprednol etabonate 0.5% gel in the treatment of ocular inflammation and pain after cataract surgery. [3]

Loteprednol etabonate 0.5% versus prednisolone acetate 1.0% for the treatment of inflammation after cataract surgery. [4]

References:

[1] J.F.Howes, Pharmazie., 2000, 55(3), pp 178-183.

[2] J.D.Sheppard, et al, J. Ocul. Pharmacol. Ther., 2011, 27(1), pp 23-27.

[3] R.K.Rajpal, et al, Cataract. Refract. Surg., 2013, 39(2), pp 158-167.

[4] S.S.Lane, et al, J. Cataract. Refract. Surg., 2013, 39(2), pp 168-173.

Signal Word

Hazard Statements

Precautionary Statements

HS Code

RIDADR

Legal Information

Not a hazardous substance or mixture

2937220000

NONH for all modes of transport

1. Product Specification

Product Specification_Loteprednol etabonate

2. Safety Data Sheet

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