Loteprednol etabonate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
CDDD 5604, HGP 1, P 5604
API & Intermediates
KAPI0F06
82034-46-6
MFCD00870765
329825544
5461012
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Loteprednol etabonate
C24H31ClO7
466.95
≥98%(HPLC)
White to Beige Solid
220-223°C
10g,20g,50g,100g,500g,1kg and 5kg
-20°C Freezer
Loteprednol etabonate ((11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-Androsta-1,4-diene-17-carboxylic acid chloromethyl ester) is a "soft" steroid, typically used in topical applications for inflammatory conditions of the eye. It is an agonist of both glucocorticoid and mineralcorticoid receptors.
Loteprednol etabonate: a review of ophthalmic clinical studies. [1]
Topical loteprednol pretreatment reduces cyclosporine stinging in chronic dry eye disease. [2]
Efficacy and safety of loteprednol etabonate 0.5% gel in the treatment of ocular inflammation and pain after cataract surgery. [3]
Loteprednol etabonate 0.5% versus prednisolone acetate 1.0% for the treatment of inflammation after cataract surgery. [4]
References:
[1] J.F.Howes, Pharmazie., 2000, 55(3), pp 178-183.
[2] J.D.Sheppard, et al, J. Ocul. Pharmacol. Ther., 2011, 27(1), pp 23-27.
[3] R.K.Rajpal, et al, Cataract. Refract. Surg., 2013, 39(2), pp 158-167.
[4] S.S.Lane, et al, J. Cataract. Refract. Surg., 2013, 39(2), pp 168-173.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture


2937220000
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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