LOXO-195

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
LOXO195
API & Intermediates
KAPI1F20
2097002-61-2

129103609

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
LOXO-195
C20H21FN6O
380.43
≥98% (HPLC)
White to Off-white Solid

500mg,1g,5g,10g,25g,50g and 100g
Store at -20°C temp.
LOXO-195 is a potent and selective TRK inhibitor designed to overcome acquired resistance that may emerge in patients receiving larotrectinib (LOXO-101) or multikinase inhibitors with anti-TRK activity.
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. [1]
Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. [2]
Reference:
[1] A.Drilon, et al, Cancer Discov., 2017, 7(9), pp 963-972.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Not classified as a hazardous substance or mixture


2934990300
NONH for all modes of transport

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1. Product Specification
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