Macitentan

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
ACT-064992
API & Intermediates
KAPI0F19
441798-33-0
MFCD17167076
16004692

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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Macitentan
C19H20Br2N6O4S
588.27
≥99%(HPLC)
White Solid
133-135°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Macitentan (also known as ACT-064992) is an orally active endothelin receptor antagonist for the treatment of pulmonary arterial hypertension (PAH).
Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. [1]
Macitentan: entry-into-humans study with a new endothelin receptor antagonist. [2]
Macitentan for the treatment of pulmonary arterial hypertension. [3]
Complement-binding anti-HLA antibodies and kidney transplantation. [4]
References:
[1] M.Iglarz, et al, J. Pharmacol. Exp. Ther., 2008, 327(3), pp 736-745.
[2] P.N.Sidharta. et al, Eur. J. Clin. Pharmacol., 2011, 67(10), pp 977-984.
[3] I.S. Hong, et al, Ann. Pharmacother., 2014, 48(4), pp 538-547.
[4] C.Lawrence, et al, N. Engl. J. Med., 2014, 370(1), pp 84-85.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



NONH for all modes of transport
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