Macitentan

Synonym

Product Category

Product Code

CAS Number

MDL Number

Pubchem CID

Reaxys RN

ACT-064992

API & Intermediates

KAPI0F19

441798-33-0

MFCD17167076

16004692

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png

Specification
Applications
Safety & Regulations
Product Documents

Chemical Name

Molecular Formula

Molecular Weight

Assay

Appearance

Melting Point

Packaging

Storage

Macitentan

C₁₉H₂₀Br₂N₆O₄S

588.27

≥99%(HPLC)

White Solid

133-135°C

500mg,1g,10g,25g,50g,100g and 500g

-20°C Freezer

Macitentan (also known as ACT-064992) is an orally active endothelin receptor antagonist for the treatment of pulmonary arterial hypertension (PAH).

Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. [1]

Macitentan: entry-into-humans study with a new endothelin receptor antagonist. [2]

Macitentan for the treatment of pulmonary arterial hypertension. [3]

Complement-binding anti-HLA antibodies and kidney transplantation. [4]

References:

[1] M.Iglarz, et al, J. Pharmacol. Exp. Ther., 2008, 327(3), pp 736-745.

[2] P.N.Sidharta. et al, Eur. J. Clin. Pharmacol., 2011, 67(10), pp 977-984.

[3] I.S. Hong, et al, Ann. Pharmacother., 2014, 48(4), pp 538-547.

[4] C.Lawrence, et al, N. Engl. J. Med., 2014, 370(1), pp 84-85.

Signal Word

Hazard Statements

Precautionary Statements

HS Code

RIDADR

Legal Information

Not classified as a dangerous goods

NONH for all modes of transport

Sales restrictions may apply.

1. Product Specification

Product Specification_Macitentan

2. Safety Data Sheet

Available on request.

Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.