Mometasone furoate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Sch-32088, Elocon, Nasonex, Twisthaler, Asmanex,Ecural, Elocom
API & Intermediates
KAPI0F36
83919-23-7
MFCD00866003
441336
4340538
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Mometasone furoate
C27H30Cl2O6
521.43
≥98% (HPLC)
White to Slightly pale yellow Solid
212-216°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at 2-8°C temp.
Mometasone Furoate is a glucocorticoid or corticosteroid used topically to reduce inflammation of the skin or in the airways. It is a prodrug of the free form mometasone.
The inhibitory effects of topically active glucocorticoids on IL-4, IL-5, and interferon-gamma production by cultured primary CD4+ T cells. [1]
In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. [2]
A review of the pharmacology and pharmacokinetics of inhaled fluticasone propionate and mometasone furoate. [3]
Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis. [4]
Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes. [5]
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression. [6]
Mometasone Furoate Suppresses PMA-Induced MUC-5AC and MUC-2 Production in Human Airway Epithelial Cells. [7]
References:
[1] S.P.Umland, et al, J. Allergy Clin. Immunol., 1997, 100(4), pp 511-519.
[2] C.L.Smith, et al, Arzneimi Helforschung, 1998, 48(9), pp 956-960.
[3] C.Crim, et al, Clin. Ther., 2001, 23(9), pp 1339-1354.
[4] A.M.Wilson, et al, Clin. Exp. Allergy, 2001, 31(1), pp 61-68.
[5] K.P.Madauss, et al, J. Med. Chem., 2004, 47(13), pp 3381-3387.
[6] I.T. Bijsmans, et al, Sci. Rep., 2015, 5(14086), pp 1-12.
[7] O. Poachanukoon, et al, Tuberc. Respir. Dis.(Seoul), 2017, 80(1), pp 60-68.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Not a dangerous goods


2937220000
NONH for all modes of transport
TU3822000

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