N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
AZD9291 intermediate 2, Osimertinib intermediate 2
API & Intermediates
KUMI1F85
1421372-94-2
MFCD28167946
71239058
23334274
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine
C20H16FN5O3
393.38
≥99%
Yellow Solid

5g,10g,25g,50g,100g and 500g
Store at 2-8°C
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine is a pharmaceutical intermediate for the synthesis of Osimertinib (AZD9291) used to treat non-small-cell lung carcinomas with a specific mutation.
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. [1]
Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants. [2]
References:
[1] M.R.Finlay, et al, J. Med. Chem., 2014, 57(20), pp 8249-8267.
[2] H.Zhang, et al, Eur. J. Med. Chem., 2017, 135, pp 12-23.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Available on request.
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