Naftifine hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
(E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine HCL
API & Intermediates
KAPI0F02
65473-14-5
MFCD00059047
329750513
6451298
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Naftifine hydrochloride
C21H22ClN
323.86
≥99%
White to Off-white Solid
175-180°C
50g,100g,500g,1kg and 5kg
Store at room temperature
Naftifine hydrochloride ((E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine hydrochloride) is a typical  Active Pharmaceutical Ingredients (API) for the synthesis of allylamine antifungal and antimycotic drug, Naftifine(brand name Exoderil), for the topical treatment of tinea pedis, tinea cruris and tinea corporis (fungal infections). Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. It also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.
In vitro activity of naftifine, a new antifungal agent. [1]
Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics. [2]
In vitro antifungal activity of naftifine hydrochloride against dermatophytes. [3]
An Open-Label, Multi-Center, Multiple-Application Pharmacokinetic Study of Naftifine HCl Gel 2% in Pediatric Subjects With Tinea Pedis. [4]
New Antifungal Agents and New Formulations Against Dermatophytes. [5]
References:
[1] A.Georgopoulos, et al, Antimicrob. Agents Chemother., 1981, 19(3), pp 386-389.
[2] A.Stuetz, et al, J. Med. Chem., 1986, 29(1), pp 112-125.
[3] M.Ghannoum, et al, Antimicrob. Agents Chemother., 2013, 57(9), pp 4369-4372.
[4] A.Verma, et al, J. Drugs Dermatol., 2015, 14(7), pp 686-691.
[5] A.K.Gupta, et al, Mycopathologia, 2017, 182(1-2), pp 127-141.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture


29214900900
NONH for all modes of transport
Sales restrictions may apply.
1. Product Specification
For further information and support on USP Reference Standard, please go to the website of the issuing pharmacopoeia.
2. Safety Data Sheet
SDS issued by USP can be found here.
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