Nintedanib esylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Nintedanib Ethanesulfonate Salt, BIBF1120 esylate
API & Intermediates
KAPI0F13
656247-18-6
MFCD26142360
9809714
14300928
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Nintedanib esylate
C31H33N5O4•C2H6O3S
649.76
≥99.8%(HPLC)
Bright Yellow Solid
295-305°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Nintedanib esylate (also known as Nintedanib Ethanesulfonate Salt, BIBF1120 esylate) is the ethanesulfonate salt form of BIBF1120 (Nintedanib), which is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. [1]
An Open-label Dose-escalation Study of BIBF 1120 in Patients with Relapsed or Refractory Multiple Myeloma. [2]
A randomized phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer (OC). [3]
A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies. [4]
Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors. [5]
Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients. [6]
Nintedanib: a novel therapeutic approach for idiopathic pulmonary fibrosis. [7]
New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses. [8]
Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer: a network meta-analysis. [9]
Nintedanib in the treatment of idiopathic pulmonary fibrosis. [10]
Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties. [11]
Nintedanib in patients with idiopathic pulmonary fibrosis: Combined evidence from the TOMORROW and INPULSIS® trials. [12]
Clinical use of nintedanib in patients with idiopathic pulmonary fibrosis. [13]
References:
[1] F.Hillberg, et al, Cancer Res., 2008, 68(12), pp 4774-4782.
[2] M.Kropff, et al, Anticancer Res., 2009, 29(10), pp 4233-4238.
[3] J.A.Ledermann, et al, J. Clin. Oncol., 2009, 27(15s), pp 5501-5501.
[4] A.du Bois, et al, Ann. Oncol., 2010, 21(2), pp 370-375.
[5] K.Mross, et al, Clin. Cancer Res., 2010, 16(1), pp 311-319.
[6] P.M.Ellis, et al, Clin. Cancer Res., 2010, 16(10), pp 2881-2889.
[7] I.A.Dimitroulis, et al, Respir. Care., 2014, 59(9), pp 1450-1455.
[8] N.Ahluwalia, et al, Am. J. Respir. Crit. Care Med., 2014, 190(8), pp 867-878.
[9] S.Popat, et al, Future Oncol., 2015, 11(3), pp 409-420.
[10] M.E.Mazzei, et al, Ther. Adv. Respir. Dis., 2015, 9(3), pp 121-129.
[11] R.Xu, et al, J. Labelled Comp. Radiopharm., 2015, 58(7), pp 308-312.
[12] L.Richeldi, et al, Respir. Med., 2016, 113, pp 74-79.
[13] A.Hajari Case ,et al, BMJ Open Resp. Res., 2017, 4(1), e000192.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



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