Olaparib

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Lynparza, AZD-2281, AZD 2281
API & Intermediates
KAPI1F03
763113-22-0
MFCD13185161
23725625

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Olaparib
C24H23FN4O3
434.47
≥99%(HPLC)
White to Off-white Solid
207-210°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Olaparib (also known as Lynparza, AZD-2281, AZD 2281) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. It is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways.
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. [1]
Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. [2]
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP. [3]
Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer? [4]
The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy. [5]
Role of PARP inhibitors in cancer biology and therapy. [6]
References:
[1] V.J.Weston, et al, Blood, 2010, 116(22), pp 4578-4587.
[2] J.M.Senra, et al, Mol. Cancer Ther., 2011, 10(10), pp 1949-1958.
[3] Y.Yuan, et al, J. Hematol. Oncol., 2011, 4(16), pp 1-14.
[4] R.Plummer, Breast Cancer Res., 2011, 13(4), pp 219:1-6.
[5] M.Javle, et al, Ther. Adv. Med. Oncol., 2011, 3(6), pp 257-267.
[6] D.Davar, et al, Curr. Med. Chem., 2012, 19(23), pp 3907-3921.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H301,H360,H372
P264,P201,P202,P281,P260,P301+P310,P330,P308+P313,P314

NONH for all modes of transport
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1. Product Specification
2. Safety Data Sheet
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