PalbociclibIsethionate(also known as PD 0332991 Isethionate, PD 332991Isethionate) is a potent selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6 for the treatment of ER-positive and HER2-negative breast cancer.
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro.
Palbociclib (PD 0332991) : targeting the cell cycle machinery in breast cancer.
Recent advances of highly selective CDK4/6 inhibitors in breast cancer.
 R.S.Finn, et al, Breast Cancer Res., 2009, 11(5), pp R77-.