Palbociclib Isethionate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
PD0332991 Isethionate, PD 0332991 Isethionate
API & Intermediates
KAPI0F24
827022-33-3
MFCD22666589
11478676

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Palbociclib Isethionate
C24H29N7O2•C2H6O4S
573.66
≥99%(HPLC)
Yellow Solid
>248°C
500mg,1g,10g,25g,50g,100g and 500g
-20°C Freezer
Palbociclib Isethionate (also known as PD 0332991 Isethionate, PD 332991 Isethionate) is a potent selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6 for the treatment of ER-positive and HER2-negative breast cancer.
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. [1]
Palbociclib (PD 0332991) : targeting the cell cycle machinery in breast cancer. [2]
Recent advances of highly selective CDK4/6 inhibitors in breast cancer. [3]
References:
[1] R.S.Finn, et al, Breast Cancer Res., 2009, 11(5), pp R77-.
[2] A.Rocca, et al, Expert. Opin. Pharmacother., 2014, 15(3), pp 407-420.
[3] H.Xu, et al, J. Hematol. Oncol., 2017, 10, pp 97:1-12.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301
P301+P310
2933599590
UN 2811 6.1/PG III
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1. Product Specification
2. Safety Data Sheet
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