Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Votrient, GW786034B, GSK-VEG10003
API & Intermediates
KAPI0F21
444731-52-6
MFCD11616589
10113978
Pazopanib (also known as Votrient, GW786034B, GSK-VEG10003) is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit, which blocks tumour growth and inhibits angiogenesis. It is typically used to treat renal cell carcinoma and soft tissue sarcoma.
The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma . [1]
Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). [2]
Comprehensive analysis of kinase inhibitor selectivity. [3]
Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer. [4]
Concise Drug Review: Pazopanib and Axitinib. [5]
Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use. [6]
Optimal first-line and second-line treatments for metastatic renal cell carcinoma: current evidence. [7]
References:
[1] K.Podar, et al, Proc. Natl. Acad. Sci. USA, 2006, 103(51), pp 19478-19483.
[2] S.Sleijfer, et al, J. Clin. Oncol., 2009, 27(19), pp 3126-3132.
[3] M.I.Davis, et al, Nat. Biotechnol., 2011, 29(11), pp 1046-1051.
[4] S.V.Ulahannan, et al, Cancer Invest., 2011, 29(4), pp 325-337.
[5] R.M.J.M.van Geel, et al, Oncologist, 2012, 17(8), pp 1081-1089.
[6] J.C.Uitdehaag, et al, PLoS One, 2014, 9(3), pp e92146:1-13.
[7] M.Sun, et al, Int. Nephrol. Renovasc. Dis., 2014, 7, pp 401-407.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
P302,P315,P319,P335
P261,P264,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P312
NONH for all modes of transport
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