1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Penfluridol, Semap, Micefal, Longoperidol
Fluorinated Building Blocks, API & Intermediates
KAPI5F01
26864-56-2
MFCD00866714
33630
1558826
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-(2-fluorophenyl)-1H-pyrrol-3-carboxaldehyde
C28H27ClF5NO
523.97
≥98% (HPLC)
White Solid
106-108°C
1g,2g,5g,10g,25g,50g,100g,200g and 500g
Store at -20°C temp.
Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic used as calcium channel antagonist.
Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists. [1]
Preferential block of T-type calcium channels by neuroleptics in neural crest-derived rat and human C cell lines. [2]
Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers. [3]
Beta subunit coexpression and the alpha1 subunit domain I-II linker affect piperidine block of neuronal calcium channels. [4]
References:
[1] R.J.Gould, et al, Proc. Natl. Acad. Sci. U.S.A, 1983, 80(16), pp 5122-5125.
[2] J.J.Enyeart, et al, Mol. Pharmacol., 1992, 42(2), pp 364-372.
[3] J.W.Daly, et al, Biochem. Pharmacol., 1995, 50(8), pp 1187-1197.
[4] G.W. Zamponi, et al, J. Neurosci., 1996, 16(8), pp 2430-2443.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Danger
H301
P301+P310
2933399990
UN 2811 6.1/PG III
TN6957000

1. Product Specification
2. Safety Data Sheet
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