Roflumilast N-oxide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Daxas N-oxide
API & Intermediates
KUMI2F131
292135-78-5
MFCD04112984 
9940999
10715186
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Roflumilast N-oxide
C17H14Cl2F2N2O4
419.21
≥98% (HPLC)
White to Slightly pale reddish yellow Solid
179-183°C
5g,10g,25g,50g,100g,250g and 500g
Store at 2-8°C temp.
Roflumilast N-oxide is the pharmacodynamically active metabolite of roflumilast, which is an oral, once-daily phosphodiesterase 4 (PDE4) inhibitor.
Effect of fluvoxamine on the pharmacokinetics of roflumilast and roflumilast N-oxide. [1]
Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects. [2]
A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro. [3]
Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro. [4]
Roflumilast N-Oxide in Combination with Formoterol Enhances the Antiinflammatory Effect of Dexamethasone in Airway Smooth Muscle Cells. [5]
References:
[1] O.Von Richter, et al, Clin. Pharmacokinet., 2007, 46(7), pp 613-622.
[2] N.Nassr, et al, Br. J. Clin. Pharmcol., 2009, 68(4), pp 580-587.
[3] F.Sabatini, et al, Pulm. Pharmcol. Ther., 2010, 23(4), pp 283-291.
[4] J.Milara, et al, Br. J. Pharmacol., 2012, 166(8), pp 2243-2262.
[5] B.S.Patel, Am. J. Respir. Cell Mol. Biol., 2017, 56(4), pp 532-538.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
RETCS
Legal Information
Warning
H315,H319
P264,P280,P305+P351+P338

NONH for all modes of transport


1. Product Specification
2. Safety Data Sheet
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