Roflumilast(also known as B 9302-107, BYK 20869) is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 0.8 nM. It has anti-inflammatory properties and is used clinically for the treatment of the chronic obstructive pulmonary disease (COPD).
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.
The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis.
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease.